Association of candidate single nucleotide polymorphisms with somatic mutation of the epidermal growth factor receptor pathway.
Details
Publication Year 2013-10-23, Volume 6, Issue #1, Page 43
Journal Title
BMC Medical Genomics
Publication Type
JOURNAL ARTICLE
Abstract
Tumour growth in colorectal cancer and other solid cancers is frequently supported by activating mutations in the epidermal growth factor receptor (EGFR) signaling pathway (Patholog Res Int 2011:932932, 2011). Treatment of metastatic colorectal cancer with targeted anti-EGFR therapeutics such as cetuximab extends survival in only 25% of patients who test wild-type for KRAS, while the majority of patients prove resistant (J Clin Oncol 28(7):1254--1261, 2010).Prediction of cetuximab responsiveness for KRAS wild-type colorectal cancers is currently not well defined, and prognostic biomarkers would help tailor treatment to individual patients. Somatic mutation of the EGFR signalling pathway is a prevalent mechanism of resistance to cetuximab (Nature 486(7404):532--536, 2012). If the human genome harbours variants that influence susceptibility of the EGFR pathway to oncogenic mutation, such variants could also be prognostic for cetuximab responsiveness.
Publisher
BioMed Central
Keywords
Metastatic Colorectal Cancer ; EGFR signalling pathway somatic mutation
WEHI Research Division(s)
Systems Biology And Personalised Medicine
Open Access at Publisher's Site
http://www.biomedcentral.com/1755-8794/6/43
Rights Notice
© 2013 Wormald et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Creation Date: 2013-10-23 12:00:00
Last Modified: 0001-01-01 12:00:00
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