The Use of JAK-specific inhibitors as chemical biology tools.
Journal Title
Methods in Molecular Biology
Publication Type
Journal Article
Abstract
The JAK family of protein tyrosine kinases are now recognized as important participants in a wide range of pathologies, from cancer to inflammatory diseases. In the last decade, the drive to develop drugs targeting members of this family has begun to deliver a panel of small molecule inhibitors of JAK family members, with a range of potencies and specificities. A number of these compounds have already found widespread use as biochemical tools in the elucidation of JAK activity in specific signaling and disease processes; however, many of the first generation compounds are poorly characterized with suboptimal potencies and selectivities.Herein, we present the data for those small molecule JAK inhibitors that have been described in the peer-reviewed literature and the benefits and potential issues that may be associated with the use of these tool compounds.
Publisher
Springer
Keywords
Janus Kinases ; Protein Kinase ; Kinase Inhibitor ; JAK Inhibitor ; Chemical Probe
WEHI Research Division(s)
Chemical Biology
Rights Notice
© Springer, Part of Springer Science+Business Media


Creation Date: 2013-01-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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