Regulation of murine natural killer cell commitment.
- Author(s)
- Huntington, ND; Nutt, SL; Carotta, S;
- Journal Title
- Frontiers in Immunology
- Publication Type
- Journal Article
- Abstract
- Natural killer (NK) cells can derive from the same precursors as B and T cells, however, to achieve lineage specificity, several transcription factors need to be activated or annulled. While a few important transcription factors have been identified for NK genesis the mechanisms of how this is achieved is far from resolved. Adding to the complexity of this, NK cells are found and potentially develop in diverse locations in vivo and it remains to be addressed if a common NK cell precursor seeds diverse niches and how transcription factors may differentially regulate NK cell commitment in distinct microenvironments. Here we will summarize some recent findings in NK cell commitment and discuss how a NK cell transcriptional network might be organized, while addressing some misconceptions and anomalies along the way.
- Publisher
- Frontiers Media
- Keywords
- innate lymphocytes ; natural killer cells, ; development ; pre-pro NK cells ; transcription factors ; differentiation ; ID2 ; NFIL3
- Research Division(s)
- Molecular Immunology
- Link To PubMed Central Version
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558707/#__ffn_sectitle
- Publisher's Version
- https://doi.org/10.3389/fimmu.2013.00014
- Open Access at Publisher's Site
http://www.frontiersin.org/Journal/10.3389/fimmu.2013.00014/full- Terms of Use/Rights Notice
- Copyright: © 2013 Huntington, Nutt and Carotta. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
Creation Date: 2013-01-30 12:00:00