Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein
Details
Publication Year 2013-11, Volume 14, Issue #11, Page 992-8
Journal Title
EMBO reports
Publication Type
Journal Article
Abstract
The BH3-only protein Bim is a critical initiator of apoptosis in hematopoietic cells. Bim is upregulated in response to growth factor withdrawal and in vitro studies have implicated the transcription factor Foxo3a as a critical inducer. To test the importance of this regulation in vivo, we generated mice with mutated Foxo-binding sites within the Bim promoters (Bim(DeltaFoxo/DeltaFoxo)). Contrary to Bim-deficient mice, Bim(DeltaFoxo/DeltaFoxo) mice had a normal hematopoietic system. Moreover, cytokine-dependent haematopoietic cells from Bim(DeltaFoxo/DeltaFoxo) and wt mice died at similar rates. These results indicate that regulation of Bim by Foxo transcription factors is not critical for the killing of hematopoietic cells.
Publisher
European Molecular Biology Organization
Keywords
Apoptosis ; Bcl‐2 ; BH3‐Only ; Proteins ; Bim ;Hematopoiesis
WEHI Research Division(s)
Molecular Genetics Of Cancer
Rights Notice
Copyright© 2013 European Molecular Biology Organization


Creation Date: 2014-01-16 05:22:01
Last Modified: 0001-01-01 12:00:00
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