Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein
- Author(s)
- Herold, MJ; Rohrbeck, L; Lang, MJ; Grumont, R; Gerondakis, S; Tai, L; Bouillet, P; Kaufmann, T; Strasser, A;
- Details
- Publication Year 2013-11,Volume 14,Issue #11,Page 992-8
- Journal Title
- EMBO reports
- Publication Type
- Journal Article
- Abstract
- The BH3-only protein Bim is a critical initiator of apoptosis in hematopoietic cells. Bim is upregulated in response to growth factor withdrawal and in vitro studies have implicated the transcription factor Foxo3a as a critical inducer. To test the importance of this regulation in vivo, we generated mice with mutated Foxo-binding sites within the Bim promoters (Bim(DeltaFoxo/DeltaFoxo)). Contrary to Bim-deficient mice, Bim(DeltaFoxo/DeltaFoxo) mice had a normal hematopoietic system. Moreover, cytokine-dependent haematopoietic cells from Bim(DeltaFoxo/DeltaFoxo) and wt mice died at similar rates. These results indicate that regulation of Bim by Foxo transcription factors is not critical for the killing of hematopoietic cells.
- Publisher
- European Molecular Biology Organization
- Keywords
- Apoptosis ; Bcl‐2 ; BH3‐Only ; Proteins ; Bim ;Hematopoiesis
- Research Division(s)
- Molecular Genetics Of Cancer
- Link To PubMed Central Version
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818073/
- Publisher's Version
- https://doi.org/10.1038/embor.2013.152
- Terms of Use/Rights Notice
- Copyright© 2013 European Molecular Biology Organization
Creation Date: 2014-01-16 05:22:01