Homeostatic control of regulatory T cell diversity
- Details
- Publication Year 2014-01-31,Volume 14,Issue #3,Page 154-65
- Journal Title
- Nature Reviews Immunology
- Publication Type
- Journal Article
- Abstract
- Regulatory T (TReg) cells constitute an essential counterbalance to adaptive immune responses. Failure to maintain appropriate TReg cell numbers or function leads to autoimmune, malignant and immunodeficient conditions. Dynamic homeostatic processes preserve the number of forkhead box P3-expressing (FOXP3+) TReg cells within a healthy range, with high rates of cell division being offset by apoptosis under steady-state conditions. Recent studies have shown that TReg cells become specialized for different environmental contexts, tailoring their functions and homeostatic properties to a wide range of tissues and immune conditions. In this Review, we describe new insights into the molecular controls that maintain the steady-state homeostasis of TReg cells and the cues that drive TReg cell adaptation to inflammation and/or different locations. We highlight how differing local milieu might drive context-specific TReg cell function and restoration of immune homeostasis, and how dysregulation of these processes can precipitate disease.
- Publisher
- NATURE PUBLISHING GROUP
- Research Division(s)
- Immunology; Molecular Genetics Of Cancer
- PubMed ID
- 24481337
- Publisher's Version
- https://doi.org/10.1038/nri3605
- Terms of Use/Rights Notice
- © 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Creation Date: 2014-01-14 03:36:37
Last Modified: 2018-01-16 11:15:32