Suppression of cytokine signaling: The SOCS perspective
- Author(s)
- Linossi, EM; Babon, JJ; Hilton, DJ; Nicholson, SE;
- Details
- Publication Year 2013-06,Volume 24,Issue #3,Page 241-248
- Journal Title
- CYTOKINE & GROWTH FACTOR REVIEWS
- Publication Type
- Journal Article
- Abstract
- The discovery of the Suppressor of Cytokine Signaling (SOCS) family of proteins has resulted in a significant body of research dedicated to dissecting their biological functions and the molecular mechanisms by which they achieve potent and specific inhibition of cytokine and growth factor signaling. The Australian contribution to this field has been substantial, with the initial discovery of SOCS1 by Hilton, Starr and colleagues (discovered concurrently by two other groups) and the following work, providing a new perspective on the regulation of JAK/STAT signaling. In this review, we reflect on the critical discoveries that have lead to our current understanding of how SOCS proteins function and discuss what we see as important questions for future research. (C) 2013 Elsevier Ltd. All rights reserved.
- Publisher
- ELSEVIER SCI LTD
- Keywords
- SOCS; SOCS box; Cytokine; Receptor; JAK
- Research Division(s)
- Molecular Medicine; Inflammation; Structural Biology
- Link To PubMed Central Version
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816980/
- Publisher's Version
- https://doi.org/10.1016/j.cytogfr.2013.03.005
- NHMRC Grants
- NHMRC/487922,
- Terms of Use/Rights Notice
- Copyright © 2013 Elsevier Ltd. All rights reserved.
Creation Date: 2013-06-01 12:00:00