Diversity Among Memory B Cells: Origin, Consequences, and Utility
- Author(s)
- Tarlinton, D; Good-Jacobson, K;
- Details
- Publication Year 2013-09-13,Volume 341,Issue #6151,Page 1205-1211
- Journal Title
- SCIENCE
- Publication Type
- Journal Article
- Abstract
- Immunological memory is the residuum of a successful immune response that in the B cell lineage comprises long-lived plasma cells and long-lived memory B cells. It is apparent that distinct classes of memory B cells exist, distinguishable by, among other things, immunoglobulin isotype, location, and passage through the germinal center. Some of this variation is due to the nature of the antigen, and some appears to be inherent to the process of forming memory. Here, we consider the heterogeneity in development and phenotype of memory B cells and whether particular functions are partitioned into distinct subsets. We consider also how understanding the details of generating memory may provide opportunities to develop better, functionally targeted vaccines.
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Keywords
- PRIMARY IMMUNE-RESPONSE; LIVED PLASMA-CELLS; GERMINAL CENTER FORMATION; ANTIBODY-FORMING-CELLS; FOLLICULAR DENDRITIC CELLS; HUMORAL IMMUNITY; T-CELLS; BONE-MARROW; IMMUNOGLOBULIN REPERTOIRE; IMMUNOLOGICAL MEMORY
- Research Division(s)
- Immunology
- Publisher's Version
- https://doi.org/10.1126/science.1241146
- Terms of Use/Rights Notice
- © 2014 American Association for the Advancement of Science. All Rights Reserved.
Creation Date: 2013-09-13 12:00:00