Antigen-Based Vaccination and Prevention of Type 1 Diabetes
- Author(s)
- Harrison, LC; Wentworth, JM; Zhang Y; Bandala-Sanchez, E; Bohmer, RM; Neale, AM; Stone, NL; Naselli, G; Bosco, JJ; Auyeung, P; Rashidi, M; Augstein, P; Morahan, G;
- Details
- Publication Year 2013-10,Volume 13,Issue #5,Page 616-623
- Journal Title
- CURRENT DIABETES REPORTS
- Publication Type
- Journal Article
- Abstract
- Insulin-dependent or type 1 diabetes (T1D) is a paradigm for prevention of autoimmune disease: Pancreatic beta-cell autoantigens are defined, at-risk individuals can be identified before the onset of symptoms, and autoimmune diabetes is preventable in rodent models. Intervention in asymptomatic individuals before or after the onset of subclinical islet autoimmunity places a premium on safety, a requirement met only by lifestyle-dietary approaches or autoantigen-based vaccination to induce protective immune tolerance. Insulin is the key driver of autoimmune beta-cell destruction in the nonobese diabetic (NOD) mouse model of T1D and is an early autoimmune target in children at risk for T1D. In the NOD mouse, mucosal administration of insulin induces regulatory T cells that protect against diabetes. The promise of autoantigen-specific vaccination in humans has yet to be realized, but recent trials of oral and nasal insulin vaccination in at-risk humans provide grounds for cautious optimism.
- Publisher
- CURRENT MEDICINE GROUP
- Keywords
- GLUTAMIC-ACID DECARBOXYLASE; REGULATORY T-CELLS; RANDOMIZED CONTROLLED-TRIAL; INTENSIVE INSULIN-TREATMENT; NOD MICE; ORAL INSULIN; DOUBLE-BLIND; RHEUMATOID-ARTHRITIS; AUTOIMMUNE-DISEASE; NATURAL-HISTORY
- Research Division(s)
- Molecular Medicine
- Link To PubMed Central Version
- http://rd.springer.com/
- Publisher's Version
- https://doi.org/10.1007/s11892-013-0415-7
- Terms of Use/Rights Notice
- © Springer, Part of Springer Science+Business Media
Creation Date: 2013-10-01 12:00:00