Diversity, function, and transcriptional regulation of gut innate lymphocytes.
Journal Title
Frontiers in Immunology
Publication Type
Journal Article
Abstract
The innate immune system plays a critical early role in host defense against viruses, bacteria, and tumor cells. Until recently, natural killer (NK) cells and lymphoid tissue inducer (LTi) cells were the primary members of the innate lymphocyte family: NK cells form the front-line interface between the external environment and the adaptive immune system, while LTi cells are essential for secondary lymphoid tissue formation. More recently, it has become apparent that the composition of this family is much more diverse than previously appreciated and newly recognized populations play distinct and essential functions in tissue protection. Despite the importance of these cells, the developmental relationships between different innate lymphocyte populations remain unclear. Here we review recent advances in our understanding of the development of different innate immune cell subsets, the transcriptional programs that might be involved in driving fate decisions during development, and their relationship to NK cells.
Publisher
Frontiers Research Foundation
Keywords
innate lymphocytes ; lymphoid tissue inducer cells ; progenitor cells ; transcription factors ; differentiation ;lymphoid tissue ; immune protection
Research Division(s)
Molecular Immunology
Terms of Use/Rights Notice
Copyright: © 2013 Rankin, Groom, Mielke, Seillet and Belz. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.


Creation Date: 2013-03-01 12:00:00
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