Promoting immunity during chronic infection-The therapeutic potential of common gamma-chain cytokines
- Author(s)
- Toe, JG; Pellegrini, M; Mak, TW;
- Details
- Publication Year 2013-11,Volume 55,Issue #1-2,Page 38-47
- Journal Title
- MOLECULAR IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The continued global burden wrought by chronic infectious disease is unrelenting. Current therapies have curbed the severity of disease for patients, but Human Immunodeficiency Virus (HIV) and Hepatitis B (HBV) infection remain incurable and Mycobacterium tuberculosis (MTB) is rapidly becoming resistant to our existing antibiotics. Much attention has been given to enhancing T cell immunity through the use of certain common gamma-chain cytokines, which have proven to be essential and necessary for T cell survival and function. This article reviews the pre-clinical and clinical literature surrounding IL-2, IL-7, IL-15 and IL-21 and we comment on the potential therapeutic promise of these cytokines as adjuvant treatments for chronic infectious diseases. (C) 2013 Elsevier Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Common gamma-chain; Cytokines; HIV; Infection; CD8(+) T cell; Therapy
- Research Division(s)
- Infection And Immunity
- Publisher's Version
- https://doi.org/10.1016/j.molimm.2013.04.008
- Terms of Use/Rights Notice
- Copyright © 2013 Elsevier Ltd. All rights reserved.
Creation Date: 2013-11-01 12:00:00