Mechanisms of cell division as regulators of acute immune response
- Author(s)
- Kan, Andrey; Hodgkin, PD;
- Details
- Publication Year 2014-04-29,Volume 8,Issue #3,Page 215-112
- Journal Title
- Systems and Synthetic Biology
- Publication Type
- Journal Article
- Abstract
- The acute adaptive immune response is complex, proceeding through phases of activation of quiescent lymphocytes, rapid expansion by cell division and cell differentiation, cessation of division and eventual death of greater than 95 % of the newly generated population. Control of the response is not central but appears to operate as a distributed process where global patterns reliably emerge as a result of collective behaviour of a large number of autonomous cells. In this review, we highlight evidence that competing intracellular timed processes underlie the distribution of individual fates and control cell proliferation, cessation and loss. These principles can be captured in a mathematical model to illustrate consistency with previously published experimentally observed data.
- Publisher
- Springer Netherlands
- Keywords
- Cell division; Immune regulation; Mathematical modelling; B lymphocytes
- Research Division(s)
- Immunology
- PubMed ID
- 25136383
- Link To PubMed Central Version
- http://www.ncbi.nlm.nih/pmc/articles/PMC4127173/
- Publisher's Version
- https://doi.org/10.1007/s11693-014-9149-3
- Terms of Use/Rights Notice
- © Springer, Part of Springer Science+Business Media
Creation Date: 2014-05-15 08:22:59
Last Modified: 2015-09-04 11:08:25