Wnt signaling and colon tumorigenesis--a view from the periphery
- Author(s)
- Burgess, AW; Faux, MC; Layton, MJ; Ramsay, RG;
- Details
- Publication Year 2011-11-15,Volume 317,Issue #19,Page 2748-58
- Journal Title
- Exp Cell Res
- Publication Type
- Journal Article
- Abstract
- In this brief overview we discuss the association between Wnt signaling and colon cell biology and tumorigenesis. Our current understanding of the role of Apc in the beta-catenin destruction complex is compared with potential roles for Apc in cell adhesion and migration. The requirement for phosphorylation in the proteasomal-mediated degradation of beta-catenin is contrasted with roles for phospho-beta-catenin in the activation of transcription, cell adhesion and migration. The synergy between Myb and beta-catenin regulation of transcription in crypt stem cells during Wnt signaling is discussed. Finally, potential effects of growth factor regulatory systems, Apc or truncated-Apc on crypt morphogenesis, stem cell localization and crypt fission are considered.
- Publisher
- Elsevier
- Publisher's Version
- https://doi.org/10.1016/j.yexcr.2011.08.010
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2014-05-14 03:05:54