Wnt signaling and colon tumorigenesis--a view from the periphery
Publication Year 2011-11-15, Volume 317, Issue #19, Page 2748-58
- Journal Title
- Exp Cell Res
- Publication Type
- Journal Article
- In this brief overview we discuss the association between Wnt signaling and colon cell biology and tumorigenesis. Our current understanding of the role of Apc in the beta-catenin destruction complex is compared with potential roles for Apc in cell adhesion and migration. The requirement for phosphorylation in the proteasomal-mediated degradation of beta-catenin is contrasted with roles for phospho-beta-catenin in the activation of transcription, cell adhesion and migration. The synergy between Myb and beta-catenin regulation of transcription in crypt stem cells during Wnt signaling is discussed. Finally, potential effects of growth factor regulatory systems, Apc or truncated-Apc on crypt morphogenesis, stem cell localization and crypt fission are considered.
- Publisher's Version
- Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2014-05-14 03:05:54Last Modified: 0001-01-01 12:00:00