Crafting the Brain - Role of Histone Acetyltransferases in Neural Development and Disease
Author(s)
Sheikh, BN;
Details
Publication Year 2014-05-02, Volume 356, Issue #3, Page 553-573
Journal Title
Cell Tissue Res
Publication Type
Journal Article
Abstract
The human brain is a highly specialized organ containing nearly 170 billion cells with specific functions. Development of the brain requires adequate proliferation, proper cell migration, differentiation and maturation of progenitors. This is in turn dependent on spatial and temporal coordination of gene transcription, which requires the integration of both cell intrinsic and environmental factors. Histone acetyltransferases (HATs) are one family of proteins that modulate expression levels of genes in a space- and time-dependent manner. HATs and their molecular complexes are able to integrate multiple molecular inputs and mediate transcriptional levels by acetylating histone proteins. In mammals, 19 HATs have been described and are separated into five families (p300/CBP, MYST, GNAT, NCOA and transcription-related HATs). During embryogenesis, individual HATs are expressed or activated at specific times and locations to coordinate proper development. Not surprisingly, mutations in HATs lead to severe developmental abnormalities in the nervous system and increased neurodegeneration. This review focuses on our current understanding of HATs and their biological roles during neural development.
Publisher
Springer
WEHI Research Division(s)
Development And Cancer
Rights Notice
# Springer-Verlag Berlin Heidelberg 2014


Creation Date: 2014-05-20 08:08:55
Last Modified: 0001-01-01 12:00:00
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