Responding to R-spondin: slit2 potentiates intestinal regeneration
- Author(s)
- Phesse, TJ; Sansom, OJ;
- Details
- Publication Year 2013-11-07,Volume 13,Issue #5,Page 512-4
- Journal Title
- Cell stem cell
- Publication Type
- Journal Article
- Abstract
- Gastrointestinal toxicity of chemoradiotherapy treatment in late-stage cancer patients limits tolerable doses and effectiveness of treatments. Zhou and colleagues in Nature (Zhou et al., 2013) suggest that activating Robo/Slit signaling in concert with R-Spondin potentiates Wnt signaling in intestinal stem cells and drives successful intestinal regeneration and recovery.
- Publisher
- Cell Press
- Research Division(s)
- Cell Signalling And Cell Death
- Publisher's Version
- https://doi.org/10.1016/j.stem.2013.10.006
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Creation Date: 2014-04-16 08:43:44