Id2 represses E2A-mediated activation of IL-10 expression in T cells
- Author(s)
- Masson, F; Ghisi, M; Groom, JR; Kallies, A; Seillet, C; Johnstone, R; Nutt, SL; Belz, GT;
- Details
- Publication Year 2014-04-10,Volume 123,Issue #22,Page 3420-8
- Journal Title
- Blood
- Publication Type
- Journal Article
- Abstract
- Interleukin (IL)-10 is a key immunoregulatory cytokine that functions to prevent inflammatory and autoimmune diseases. Despite the critical role for IL-10 produced by effector CD8+ T cells during pathogen infection and autoimmunity, the mechanisms regulating its production are poorly understood. We show that loss of the Inhibitor of DNA binding (Id) 2 in T cells resulted in aberrant IL-10 expression in vitro and in vivo during influenza virus infection and in a model of acute graft vs. host disease (GVHD). Furthermore, IL-10 over-production substantially reduced the immunopathology associated with GVHD. We demonstrate that Id2 acts to repress the E2A-mediated trans-activation of the Il10 locus. Collectively, our findings uncover a key regulatory role of Id2 during effector T cell differentiation necessary to limit IL-10 production by activated T cells and minimize their suppressive activity during the effector phase of disease control.
- Publisher
- AMER SOC HEMATOLOGY
- Research Division(s)
- Cell Signalling And Cell Death; Molecular Immunology
- Publisher's Version
- https://doi.org/10.1182/blood-2014-03-561456
- NHMRC Grants
- NHMRC/1042582,
- Terms of Use/Rights Notice
- Copyright © 2014 American Society of Hematology
Creation Date: 2014-04-16 08:43:43
Last Modified: 2015-09-07 12:18:10