EGF receptor family: twisting targets for improved cancer therapies
- Author(s)
- Burgess, AW; Henis, YI; Hynes, NE; Jovin, T; Levitzki, A; Pinkas-Kramarski, R; Yarden, Y;
- Details
- Publication Year 2014-04,Volume 32,Issue #2,Page 74-81
- Journal Title
- Growth Factors
- Publication Type
- Journal Article
- Abstract
- The epidermal growth factor receptor (EGFR) undergoes a conformational change in response to ligand binding. The ligand-induced changes in cell surface aggregation and mobility have a profound effect on the function of all the family members. Ligand also activates the EGFR intracellular kinase, stimulating proliferation and cell survival. The EGFR family are often activated, overexpressed or mutated in cancer cells and therapeutic drugs (including antibodies) can slow the progress of some cancers. This article provides a brief, annotated summary of the presentations and discussion which occurred at the Epidermal Growth Factor Receptor - Future Directions Conference held in Jerusalem in November 2013.
- Publisher
- Informa Health Care
- Research Division(s)
- Structural Biology
- Publisher's Version
- https://doi.org/10.3109/08977194.2014.896355
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2014-07-29 03:01:07