Effect of testosterone treatment on glucose metabolism in men with type 2 diabetes: a randomized controlled trial

Gianatti, EJ; Dupuis, P; Hoermann, R; Strauss, BJ; Wentworth, JM; Zajac, JD; Grossmann, M

Author(s): Gianatti, EJ; Dupuis, P; Hoermann, R; Strauss, BJ; Wentworth, JM; Zajac, JD; Grossmann, M;
Details: Publication Year 2014-05-07,Volume 37,Issue #8,Page 2098-2107
Journal Title: Diabetes Care
Publication Type: Journal Article
Abstract: OBJECTIVETo determine whether testosterone therapy improves glucose metabolism in men with type 2 diabetes (T2D) and lowered testosterone.RESEARCH DESIGN AND METHODSWe conducted a randomized, double-blind, parallel, placebo-controlled trial in 88 men with T2D, aged 35-70 years with an HbA1c </=8.5% (69 mmol/mol), and a total testosterone level, measured by immunoassay, of </=12.0 nmol/L (346 ng/dL). Participants were randomly assigned to 40 weeks of intramuscular testosterone undecanoate (n = 45) or matching placebo (n = 43). All study subjects were included in the primary analysis. Seven men assigned to testosterone and six men receiving placebo did not complete the study. Main outcome measures were insulin resistance by homeostatic model assessment (HOMA-IR, primary outcome) and glycemic control by HbA1c (secondary outcome).RESULTSTestosterone therapy did not improve insulin resistance (mean adjusted difference [MAD] for HOMA-IR compared with placebo -0.08 [95% CI -0.31 to 0.47; P = 0.23]) or glycemic control (MAD HbA1c 0.36% [0.0, 0.7]; P = 0.05), despite a decrease in fat mass (MAD -2.38 kg [-3.10 to -1.66]; P < 0.001) and an increase in lean mass (MAD 2.08 kg [1.52-2.64]; P < 0.001). Testosterone therapy reduced subcutaneous (MAD -320 cm3 [-477, -163]; P < 0.001) but not visceral abdominal adipose tissue (MAD 140 cm3 [-89 to 369]; P = 0.90).CONCLUSIONSTestosterone therapy does not improve glucose metabolism or visceral adiposity in obese men with moderately controlled T2D and modest reductions in circulating testosterone levels typical for men with T2D.
Publisher: American Diabetes Association
Research Division(s): Molecular Medicine
PubMed ID: 24804695
Publisher's Version: https://doi.org/10.2337/dc13-2845
Terms of Use/Rights Notice: © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

Creation Date: 2014-06-06 08:31:26

Last Modified: 2015-09-16 11:26:59