Mammary stem cells and the differentiation hierarchy: current status and perspectives
- Author(s)
- Visvader, JE; Stingl, J;
- Details
- Publication Year 2014-06-01,Volume 28,Issue #11,Page 1143-1158
- Journal Title
- Genes Dev
- Publication Type
- Journal Article
- Abstract
- The mammary epithelium is highly responsive to local and systemic signals, which orchestrate morphogenesis of the ductal tree during puberty and pregnancy. Based on transplantation and lineage tracing studies, a hierarchy of stem and progenitor cells has been shown to exist among the mammary epithelium. Lineage tracing has highlighted the existence of bipotent mammary stem cells (MaSCs) in situ as well as long-lived unipotent cells that drive morphogenesis and homeostasis of the ductal tree. Moreover, there is accumulating evidence for a heterogeneous MaSC compartment comprising fetal MaSCs, slow-cycling cells, and both long-term and short-term repopulating cells. In parallel, diverse luminal progenitor subtypes have been identified in mouse and human mammary tissue. Elucidation of the normal cellular hierarchy is an important step toward understanding the "cells of origin" and molecular perturbations that drive breast cancer.
- Publisher
- CSH Press
- Keywords
- mammary stem cell ; development ; breast cancer ; steroid hormone ; epigenome
- Research Division(s)
- Stem Cells And Cancer
- Publisher's Version
- https://doi.org/10.1101/gad.242511.114
- Terms of Use/Rights Notice
- Copyright © 2014 by Cold Spring Harbor Laboratory Press
Creation Date: 2014-06-06 07:57:24