The unconventional expression of IL-15 and its role in NK cell homeostasis
- Author(s)
- Huntington, ND;
- Details
- Publication Year 2014-03,Volume 92,Issue #3,Page 210-3
- Journal Title
- Immunol Cell Biol
- Publication Type
- Journal Article
- Abstract
- Natural killer (NK) cells are the founding members of the innate lymphoid cell family and contribute to the rapid production of inflammatory mediators upon pathogen detection. The evolution of receptors for self major histocompatibility complex-I and stress-induced ligands also bestows upon NK cells an important effector role in the clearance of virus-infected and transformed cells. NK cells are dependent on the pleiotropic cytokine interleukin (IL)-15 for their development, differentiation and optimal function. Here I review the regulation of IL-15 in vivo, its role in driving NK cell differentiation and discuss the function of NK cell diversification with regard to innate immunity.
- Publisher
- NPG
- Research Division(s)
- Molecular Immunology
- Publisher's Version
- https://doi.org/10.1038/icb.2014.1
- NHMRC Grants
- NHMRC/1049407,
- Terms of Use/Rights Notice
- © 2014 Australasian Society for Immunology
Creation Date: 2014-07-09 09:33:57
Last Modified: 2015-05-27 10:55:58