Structure-guided rescaffolding of selective antagonists of BCL-XL
Details
Publication Year 2014-06-12, Volume 5, Issue #6, Page 662-7
Journal Title
ACS Med Chem Lett
Publication Type
Journal Article
Abstract
Because of the promise of BCL-2 antagonists in combating chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL), interest in additional selective antagonists of antiapoptotic proteins has grown. Beginning with a series of selective, potent BCL-XL antagonists containing an undesirable hydrazone functionality, in silico design and X-ray crystallography were utilized to develop alternative scaffolds that retained the selectivity and potency of the starting compounds.
Publisher
ACS
WEHI Research Division(s)
Chemical Biology; Structural Biology
Publisher's Version
https://doi.org/10.1021/ml500030p
NHMRC Grants
NHMRC/305536 NHMRC/461221 NHMRC/1016701
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2014-06-23 08:42:21
Last Modified: 2015-03-26 02:49:24
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