Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
- Author(s)
- Czabotar, PE; Lessene, G; Strasser, A; Adams, JM;
- Details
- Publication Year 2014-01,Volume 15,Issue #1,Page 49-63
- Journal Title
- Nature Reviews Molecular Cell Biology
- Publication Type
- Journal Article
- Abstract
- The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell suicide programme that is essential for development, tissue homeostasis and immunity. Too little apoptosis can promote cancer and autoimmune diseases; too much apoptosis can augment ischaemic conditions and drive neurodegeneration. We discuss the biochemical, structural and genetic studies that have clarified how the interplay between members of the BCL-2 family on mitochondria sets the apoptotic threshold. These mechanistic insights into the functions of the BCL-2 family are illuminating the physiological control of apoptosis, the pathological consequences of its dysregulation and the promising search for novel cancer therapies that target the BCL-2 family.
- Research Division(s)
- Structural Biology; Chemical Biology; Molecular Genetics Of Cancer
- Publisher's Version
- https://doi.org/10.1038/nrm3722
- NHMRC Grants
- NHMRC/1016701, NHMRC/1025201, NHMRC/1025138,
- ARC Grants
- ARC/FT0992105,
- Terms of Use/Rights Notice
- © 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Creation Date: 2014-01-17 08:17:13
Last Modified: 2015-03-24 01:28:29