SOCS3: An essential physiological inhibitor of signaling by interleukin-6 and G-CSF family cytokines
Author(s)
White, CA; Nicola, NA;
Details
Publication Year 2013-10-01, Volume 2, Issue #4, Page e25045
Journal Title
Jak-Stat
Publication Type
Journal Article
Abstract
SOCS3 is an inducible negative feedback inhibitor of cytokine signaling. Conditional deletion of SOCS3 in mice using the Cre-lox system has now been applied to a range of cell types in the steady-state and under inflammatory, pathogenic, or tumorigenic stress, with the resulting phenotypes demonstrating the effects of SOCS3 in physiological and disease contexts. Together with recent structural and biochemical studies on the mechanisms of SOCS3 binding to cytokine receptors and associated kinases, we now have a better understanding of the non-redundant roles of SOCS3 in the inhibition of cytokine signaling via the receptors gp130, G-CSFR, leptinR, and IL-12Rbeta. This review discusses the known functional activities of SOCS3 in fertility and development, inflammation, innate and adaptive immunity, and malignancy as determined by genetic studies in mice.
Publisher
Landes
Keywords
Cre-lox, G-CSF, IL-12, IL-6, JAK, LIF, SOCS3, STAT, cytokine, gp130, knockout, leptin
WEHI Research Division(s)
Cancer And Haematology
Rights Notice
Copyright © 2013 Landes Bioscience This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.


Creation Date: 2014-01-23 03:21:51
Last Modified: 2015-04-02 04:01:07
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