Distribution of genomic breakpoints in chronic myeloid leukemia: analysis of 308 patients
- Author(s)
- Ross, DM; O'Hely, M; Bartley, PA; Dang, P; Score, J; Goyne, JM; Sobrinho-Simoes, M; Cross, NCP; Melo, JV; Speed, TP; Hughes, TP; Morley, AA;
- Details
- Publication Year 2013-10,Volume 27,Issue #10,Page 2105-7
- Journal Title
- Leukemia
- Publication Type
- Journal Article
- Abstract
- Translocation breakpoints of several types of leukemia have been sequenced in order to identify factors that lead to DNA breakage (for example, topoisomerase 2 in MLL and PML-RARA leukemia).1, 2 Several studies in chronic myeloid leukemia (CML) have shown a possible association of breakpoints with ALU interspersed repeat elements (IREs),3, 4, 5, 6 but remained inconclusive due to their small sample size. We sequenced 308 BCR–ABL1 fusion genes and performed a bioinformatic analysis with greater statistical power to identify breakpoint motifs.
- Publisher
- NATURE PUBLISHING GROUP
- Research Division(s)
- Bioinformatics
- Publisher's Version
- https://doi.org/10.1038/leu.2013.116
- Terms of Use/Rights Notice
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Creation Date: 2014-01-23 01:48:56