The effects of inpatient hybrid closed-loop therapy initiated within 1 week of type 1 diabetes diagnosis
- Author(s)
- Diabetes Research in Children Network Study, Group; Type 1 Diabetes TrialNet Study, Group; Buckingham, BA; Beck, RW; Ruedy, KJ; Cheng, P; Kollman, C; Weinzimer, SA; DiMeglio, LA; Bremer, AA; Slover, R; Cantwell, M;
- Details
- Publication Year 2013-05,Volume 15,Issue #5,Page 401-8
- Journal Title
- Diabetes technology & therapeutics
- Publication Type
- Journal Article
- Abstract
- BACKGROUND: This article describes our experience with inpatient hybrid closed-loop control (HCLC) initiated shortly after the diagnosis of type 1 diabetes in a randomized trial designed to assess the effectiveness of inpatient HCLC followed by outpatient sensor-augmented pump (SAP) therapy on the preservation of beta-cell function. SUBJECTS AND METHODS: Forty-eight individuals with newly diagnosed type 1 diabetes and positive pancreatic autoantibodies (7.8-37.7 years old) received inpatient HCLC therapy for up to 93 h, initiated within 7 days of diagnosis. RESULTS: On initiation of HCLC, mean glucose concentration was 240+/-100 mg/dL. During the first day of HCLC, median of the participant's mean glucose concentrations fell rapidly to 146 mg/dL, a level of control that was sustained on Days 2 and 3 (138 mg/dL and 139 mg/dL, respectively). By Day 3, the median percentage of glucose values >250 and <60 mg/dL was <1%. During the first 2 weeks of SAP treatment at home, the median participant mean glucose level was 126 mg/dL (interquartile range, 117, 137 mg/dL), and the median percentage of values between 71 and 180 mg/dL was 85% (interquartile range, 80%, 90%). CONCLUSIONS: Inpatient HCLC followed by outpatient SAP therapy can provide a safe and effective means to rapidly reverse glucose toxicity and establish near-normal glycemic control in patients with newly diagnosed type 1 diabetes.
- Publisher
- MaryAnn Liebert
- Research Division(s)
- Molecular Medicine
- Link To PubMed Central Version
- http://online.liebertpub.com
- Publisher's Version
- https://doi.org/10.1089/dia.2013.0002
- Terms of Use/Rights Notice
- Copyright©2013 Mary Ann Liebert, Inc. publishers. All rights reserved, USA and worldwide
Creation Date: 2014-03-11 12:01:05