Apoptosis in schistosomes: toward novel targets for the treatment of schistosomiasis.
Details
Publication Year 2014-02, Volume 30, Issue #2, Page 75-84
Journal Title
Trends in parasitology
Publication Type
Journal Article
Abstract
Schistosomiasis is one of the world's major neglected tropical diseases. Recent advances in schistosome genomics and transcriptomics have identified components of an intrinsic, B cell lymphoma-2 (Bcl-2)-regulated apoptotic cell death pathway. Molecular characterization of this pathway demonstrates its similarity to that in mammals. Gene expression and functional data indicate that apoptosis is active throughout the lifecycle. Moreover, drugs that activate apoptosis in human cells kill schistosome cells, raising the prospect of developing new treatments against schistosomiasis of humans. The development of new drugs is increasingly important in the face of the potential for resistance to currently available treatments, and the lack of an effective vaccine.
Publisher
Elsevier
Keywords
schistosome; schistosomiasis; apoptosis; Bcl-2; cell death; drug targets
WEHI Research Division(s)
Structural Biology
NHMRC Grants
NHMRC/1002227 NHMRC/1024620 NHMRC/1036194
Rights Notice
Crown copyright © 2013 Published by Elsevier Ltd. All rights reserved.


Creation Date: 2014-03-05 03:52:15
Last Modified: 0001-01-01 12:00:00
An error has occurred. This application may no longer respond until reloaded. Reload 🗙