Silencing of odorant receptor genes by G protein betagamma signaling ensures the expression of one odorant receptor per olfactory sensory neuron
Publication Year 2014-02-19,Volume 81,Issue #4,Page 847-59
Journal Title
Publication Type
Journal Article
Olfactory sensory neurons express just one out of a possible approximately 1,000 odorant receptor genes, reflecting an exquisite mode of gene regulation. In one model, once an odorant receptor is chosen for expression, other receptor genes are suppressed by a negative feedback mechanism, ensuring a stable functional identity of the sensory neuron for the lifetime of the cell. The signal transduction mechanism subserving odorant receptor gene silencing remains obscure, however. Here, we demonstrate in the zebrafish that odorant receptor gene silencing is dependent on receptor activity. Moreover, we show that signaling through G protein betagamma subunits is both necessary and sufficient to suppress the expression of odorant receptor genes and likely acts through histone methylation to maintain the silenced odorant receptor genes in transcriptionally inactive heterochromatin. These results link receptor activity with the epigenetic mechanisms responsible for ensuring the expression of one odorant receptor per olfactory sensory neuron.
Cell Press
WEHI Research Division(s)
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Creation Date: 2014-04-16 08:43:40
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