Progranulin does not inhibit TNF and lymphotoxin-alpha signalling through TNF receptor 1
- Author(s)
- Etemadi, N; Webb, A; Bankovacki, A; Silke, J; Nachbur, U;
- Details
- Publication Year 2013,Volume 91,Issue #10,Page 661-4
- Journal Title
- Immunology and Cell Biology
- Publication Type
- Journal Article
- Abstract
- Progranulin (proepithelin, granulin precursor) has been recently suggested to exhibit anti-inflammatory properties by directly binding to tumour necrosis factor (TNF) receptors and thereby inhibiting TNF signalling by Tang et al. This finding was challenged by Chen et al. and no interaction between progranulin and TNF receptor (TNFR) 1 or 2 was observed. We tested the ability of recombinant progranulin from different commercial sources to inhibit TNF- or lymphotoxin-alpha-induced signalling through TNFR1. We observed that progranulin does not affect signalling and cell death induction downstream of TNF or lymphotoxin-alpha. Our results suggest that the anti-inflammatory role of progranulin is not mediated through direct inhibition of TNFR1.
- Publisher
- NPG
- Research Division(s)
- Cell Signalling And Cell Death; Systems Biology And Personalised Medicine
- Publisher's Version
- https://doi.org/10.1038/icb.2013.53
- NHMRC Grants
- NHMRC/541901, NHMRC/541902, NHMRC/602516, NHMRC/1022916, NHMRC/1025594,
- Terms of Use/Rights Notice
- © 2014 Australasian Society for Immunology
Creation Date: 2014-04-16 08:43:40
Last Modified: 2015-03-26 08:07:45