Progranulin does not inhibit TNF and lymphotoxin-alpha signalling through TNF receptor 1
Details
Publication Year 2013, Volume 91, Issue #10, Page 661-4
Journal Title
Immunology and Cell Biology
Publication Type
Journal Article
Abstract
Progranulin (proepithelin, granulin precursor) has been recently suggested to exhibit anti-inflammatory properties by directly binding to tumour necrosis factor (TNF) receptors and thereby inhibiting TNF signalling by Tang et al. This finding was challenged by Chen et al. and no interaction between progranulin and TNF receptor (TNFR) 1 or 2 was observed. We tested the ability of recombinant progranulin from different commercial sources to inhibit TNF- or lymphotoxin-alpha-induced signalling through TNFR1. We observed that progranulin does not affect signalling and cell death induction downstream of TNF or lymphotoxin-alpha. Our results suggest that the anti-inflammatory role of progranulin is not mediated through direct inhibition of TNFR1.
Publisher
NPG
WEHI Research Division(s)
Cell Signalling And Cell Death; Systems Biology And Personalised Medicine
Rights Notice
© 2014 Australasian Society for Immunology


Creation Date: 2014-04-16 08:43:40
Last Modified: 2015-03-26 08:07:45
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