Evolution of B cell responses to Clec9A-targeted antigen
- Author(s)
- Park, HY; Light, A; Lahoud, MH; Caminschi, I; Tarlinton, DM; Shortman, K;
- Details
- Publication Year 2013-11-15,Volume 191,Issue #10,Page 4919-25
- Journal Title
- Journal of immunology
- Publication Type
- Journal Article
- Abstract
- The response of B cells to Ag targeted to Clec9A on dendritic cells was followed using the hapten nitrophenol (NP) conjugated to rat Ig carrier. Injection of small amounts of NP conjugated to anti-Clec9A in the absence of adjuvants gave high and very prolonged Ab responses, approaching those obtained by high doses of nontargeted NP-protein conjugates with alum adjuvant. The response to NP-anti-Clec9A included the transient formation of germinal centers, maturation of Ab affinity, and some memory B cell formation. Serum Ab titers remained high 35 wk postimmunization, well after the initial follicular response had faded. The results suggest Clec9A-targeting strategies for improving Ab responses to vaccine Ags.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Research Division(s)
- Immunology
- Publisher's Version
- https://doi.org/10.4049/jimmunol.1301947
- Terms of Use/Rights Notice
- Copyright ©2014 by The American Association of Immunologists, Inc. All rights reserved
Creation Date: 2014-02-18 03:39:53