BTB-ZF transcription factors, a growing family of regulators of early and late B cell development
- Author(s)
- Chevrier, S; Corcoran, LM;
- Details
- Publication Year 2013-03-18,Volume 92,Issue #6,Page 481-488
- Journal Title
- Immunol Cell Biol
- Publication Type
- Journal Article
- Abstract
- The differentiation of early B-cell precursors in the bone marrow into the variety of mature and effector B-cell subsets of the periphery is a complex process that requires tight regulation at the transcriptional level. Different members of the broad complex, tramtrack, bric-à-brac and zinc finger (BTB-ZF) family of transcription factors have recently been shown to have key roles in many phases of B-cell development, including early B-cell development in the bone marrow, peripheral B-cell maturation and specialization into effector cells during an immune response. This review highlights the critical functions mediated by BTB-ZF transcription factors within the B-cell lineage and emphasizes how the deregulation of these transcription factors can lead to B-cell malignancies.Immunology and Cell Biology advance online publication, 18 March 2014; doi:10.1038/icb.2014.20.
- Publisher
- NPG
- Research Division(s)
- Molecular Immunology
- Publisher's Version
- https://doi.org/10.1038/icb.2014.20
- NHMRC Grants
- NHMRC/575500,
- Terms of Use/Rights Notice
- © 2014 Australasian Society for Immunology
Creation Date: 2014-02-18 03:39:52
Last Modified: 2015-04-02 08:23:20