Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes
- Author(s)
- Chee, J; Ko, HJ; Skowera, A; Jhala, G; Catterall, T; Graham, KL; Sutherland, RM; Thomas, HE; Lew, AM; PEAKMAN, M; Kay, TW; Krishnamurthy, B;
- Details
- Publication Year 2014-01-15,Volume 192,Issue #2,Page 572-80
- Journal Title
- Journal of Immunology
- Publication Type
- Journal Article
- Abstract
- CD8(+) T cells are critical in human type 1 diabetes and in the NOD mouse. In this study, we elucidated the natural history of islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)-specific CD8(+) T cells in NOD diabetes using MHC-tetramer technology. IGRP206-214-specific T cells in the peripheral lymphoid tissue increased with age, and their numbers correlated with insulitis progression. IGRP206-214-specific T cells in the peripheral lymphoid tissue expressed markers of chronic Ag stimulation, and their numbers were stable after diagnosis of diabetes, consistent with their memory phenotype. IGRP206-214-specific T cells in NOD mice expand, acquire the phenotype of effector-memory T cells in the islets, and emigrate to the peripheral lymphoid tissue. Our observations suggest that enumeration of effector-memory T cells of multiple autoantigen specificities in the periphery of type 1 diabetic subjects could be a reliable reporter for progression of islet pathology.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Research Division(s)
- Immunology
- Publisher's Version
- https://doi.org/10.4049/jimmunol.1302100
- Terms of Use/Rights Notice
- Copyright © 2014 by The American Association of Immunologists, Inc.
Creation Date: 2014-02-18 03:39:52
Last Modified: 2015-09-04 11:31:01