Circulating Levels of the Wnt Antagonist Dkk-3 as a Diagnostic Marker for Colorectal Cancer
Journal Title
Journal of Molecular Biomarkers & Diagnosis
Publication Type
Journal Article
Abstract
The Wnt antagonist Dickkopf-3 (Dkk-3) has been implicated in several stages of tumour development in a wide; range of human cancers, including colorectal cancer (CRC). However, the usefulness of serum Dkk-3 levels as a; diagnostic biomarker for CRC has yet to be determined. In this study we used an ELISA immunoassay to examine; serum Dkk-3 protein levels in a retrospective cohort of CRC patients (n = 89) and age, gender matched controls (n; = 46). The median concentration of Dkk-3 was significantly (p = 0.0003) lower in CRC patient serum samples (29.3; ng/ml, range 10.4 – 67.8 ng/ml) when compared to control serum samples (36.8 ng/ml, range 20.7 – 67.4 ng/ml).; Receiver operating characteristic analysis demonstrated at 90% specificity, serum Dkk-3 levels distinguished CRC; patients with 36% sensitivity (AUC = 0.69, 95% CI 0.60 – 0.78).
Publisher
OMICS Publishing Group
Keywords
Colorectal cancer; Diagnostic biomarker; Dickkopf–3; Dkk–3
WEHI Research Division(s)
Structural Biology
Rights Notice
Copyright: © 2013 Brierley GV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited


Creation Date: 2014-02-27 01:08:04
Last Modified: 0001-01-01 12:00:00
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