Ars Moriendi; the art of dying well - new insights into the molecular pathways of necroptotic cell death.

Author(s): Murphy, JM; Silke, J;
Details: Publication Year 2014-02-01,Volume 15,Issue #2,Page 155-64
Journal Title: EMBO reports
Publication Type: Journal Article
Abstract: When our time comes to die most people would probably opt for a quick, peaceful and painless exit. But the manner and timing are rarely under our direct control. Hence the Ars moriendi, literally, "The Art of Dying", two texts written in Latin around the 15th century that offered advice on how to die well according to the Christian ideals of the time. In contrast, for individual cells, the death process is frequently under their control and several signaling pathways that cause cell death, including apoptosis, pyroptosis and necroptosis, have been described. Furthermore the manner in which cells die can have good or bad consequences for the organism. In this review we will discuss how cells die via the necroptotic signaling pathway, with emphasis on recent structural work and place this work in a biological context by discussing relevant studies with knock-out animals.
Publisher: European Molecular Biology Organization
Keywords: Necroptosis ; RIP Kinases ; MLKL ; CIAP ;TNF
Research Division(s): Cell Signalling And Cell Death
Link To PubMed Central Version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989861/
Publisher's Version: https://doi.org/10.1002/embr.201337970
NHMRC Grants: NHMRC/541901, NHMRC/637342, NHMRC/1046984,

Creation Date: 2014-02-21 08:58:54

Last Modified: 2015-05-25 03:49:06