T cell immunosurveillance controls B lymphoma development.
- Author(s)
- Kallies, A;
- Journal Title
- Oncoimmunology
- Publication Type
- JOURNAL ARTICLE
- Abstract
- We recently showed a critical role for T cells in the immunosurveillance of nascent B cell lymphomas arising from mutations impacting plasma cell differentiation. Our data suggest that CD8(+) T cells continuously eliminate mutated B cells that fail to downregulate their co-stimulatory machinery and the Fas death receptor, thus constraining B lymphoma pathogenesis.
- Publisher
- Landes
- Research Division(s)
- Molecular Immunology
- Link To PubMed Central Version
- www.ncbi.nlm.nih.gov/pmc/articles/PMC4077859/
- Publisher's Version
- https://doi.org/10.4161/onci.28697
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2014-07-30 02:49:59
Last Modified: 2015-04-02 03:56:33