Immunodynamics of explanted human tumors for immuno-oncology

Dubuisson, A; Fahrner, JE; Goubet, AG; Terrisse, S; Voisin, N; Bayard, C; Lofek, S; Drubay, D; Bredel, D; Mouraud, S; Susini, S; Cogdill, A; Rebuffet, L; Ballot, E; Jacquelot, N; Thomas de Montpreville, V; Casiraghi, O; Radulescu, C; Ferlicot, S; Figueroa, DJ; Yadavilli, S; Waight, JD; Ballas, M; Hoos, A; Condamine, T; Parier, B; Gaudillat, C; Routy, B; Ghiringhelli, F; Derosa, L; Breuskin, I; Rouanne, M; Andr&#233;, F; Lebacle, C; Baumert, H; Wislez, M; Fadel, E; Cremer, I; Albiges, L; Geoerger, B; Scoazec, JY; Loriot, Y; KROEMER, G; Marabelle, A; Bonvalet, M; Zitvogel, L

Author(s): Dubuisson, A; Fahrner, JE; Goubet, AG; Terrisse, S; Voisin, N; Bayard, C; Lofek, S; Drubay, D; Bredel, D; Mouraud, S; Susini, S; Cogdill, A; Rebuffet, L; Ballot, E; Jacquelot, N; Thomas de Montpreville, V; Casiraghi, O; Radulescu, C; Ferlicot, S; Figueroa, DJ; Yadavilli, S; Waight, JD; Ballas, M; Hoos, A; Condamine, T; Parier, B; Gaudillat, C; Routy, B; Ghiringhelli, F; Derosa, L; Breuskin, I; Rouanne, M; André, F; Lebacle, C; Baumert, H; Wislez, M; Fadel, E; Cremer, I; Albiges, L; Geoerger, B; Scoazec, JY; Loriot, Y; KROEMER, G; Marabelle, A; Bonvalet, M; Zitvogel, L;
Details: Publication Year 2020-12-29,Volume 13,Issue #1,Page e12850
Journal Title: EMBO Molecular Medicine
Abstract: Decision making in immuno-oncology is pivotal to adapt therapy to the tumor microenvironment (TME) of the patient among the numerous options of monoclonal antibodies or small molecules. Predicting the best combinatorial regimen remains an unmet medical need. Here, we report a multiplex functional and dynamic immuno-assay based on the capacity of the TME to respond to ex vivo stimulation with twelve immunomodulators including immune checkpoint inhibitors (ICI) in 43 human primary tumors. This "in sitro" (in situ/in vitro) assay has the potential to predict unresponsiveness to anti-PD-1 mAbs, and to detect the most appropriate and personalized combinatorial regimen. Prospective clinical trials are awaited to validate this in sitro assay.
Publisher: Embo Press
Keywords: cancer; immune checkpoint inhibitors; immunomonitoring; precision oncology; “in sitro” assay;
Research Division(s): Immunology
PubMed ID: 33372722
Publisher's Version: https://doi.org/10.15252/emmm.202012850
Open Access at Publisher's Site: https://doi.org/10.15252/emmm.202012850
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2021-03-03 09:20:36

Last Modified: 2021-03-03 09:27:21