Hyper-reflectivity on optical coherence tomography in macular telangiectasia type 2
- Author(s)
- Tzaridis, S; Hess, K; Heeren, TFC; Bonelli, R; Holz, FG; Friedlander, M;
- Journal Title
- Retina
- Publication Type
- epub ahead of print
- Abstract
- PURPOSE: To define, characterize and classify hyper-reflectivity on optical coherence tomography (OCT) and report its prevalence in macular telangiectasia type 2 (MacTel). METHODS: In a primary cross-sectional analysis, multimodal imaging data were retrospectively analyzed. The definition of hyper-reflectivity and neovascularization on OCT followed OCT-angiography-based criteria. Eyes were graded for the presence of hyper-reflectivity and neovascularization and further categorized into three classes based on position and extent of hyper-reflectivity. In a secondary analysis, eyes were reviewed for ≥24 months using OCT-imaging. RESULTS: 322 eyes from 161 patients were analyzed in the cross-sectional analysis. Hyper-reflectivity was found in 177 (55%), and neovascular membranes in 49 (15%) eyes. Hyper-reflectivity correlated significantly with parameters indicative of disease progression. In the longitudinal analysis, 206 eyes from 103 patients were reviewed over a mean of 35.6 months. 17/86 eyes (20%) showed a de novo-development of hyper-reflectivity. 8/29 eyes (28%) with preexistent intraretinal hyper-reflectivity developed outer retinal hyper-reflectivity. A high proportion of eyes with outer retinal hyper-reflectivity (17/52 [33%]) developed neovascular membranes. CONCLUSION: Hyper-reflectivity represents a common finding in MacTel but lacks a uniform definition. We propose a hyper-reflectivity grading scale that may help to estimate disease progression and identify eyes at risk for developing neovascular membranes.
- Publisher
- Ophthalmic Communications Society, Inc.
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 33438900
- Publisher's Version
- https://doi.org/10.1097/iae.0000000000003111
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-03-09 08:05:35
Last Modified: 2021-03-09 08:18:45