Synthesis of Acyl phosphoramidates employing a modified staudinger reaction
Currie, I; Sleebs, BE;
Publication Year 2021-12-30, Volume 23, Issue #2, Page 464-468
Journal Title
Organic letters
A one-step synthesis of acyl phosphoramidates from a variety of functionalized acyl azides has been developed employing trimethylsilyl chloride as an activating agent in a modified Staudinger reaction. The methodology was further adapted to include the in situ generation of the acyl azides from a diverse selection of carboxylic acids and hydrazide starting synthons. The reaction scope was extended to include the synthesis of imidodiphosphates and the natural product Microcin C.
WEHI Research Division(s)
Chemical Biology
PubMed ID
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Creation Date: 2021-03-09 08:05:41
Last Modified: 2021-04-28 08:23:01
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