Synthesis of Acyl phosphoramidates employing a modified staudinger reaction
- Author(s)
- Currie, I; Sleebs, BE;
- Details
- Publication Year 2021-12-30,Volume 23,Issue #2,Page 464-468
- Journal Title
- Organic letters
- Abstract
- A one-step synthesis of acyl phosphoramidates from a variety of functionalized acyl azides has been developed employing trimethylsilyl chloride as an activating agent in a modified Staudinger reaction. The methodology was further adapted to include the in situ generation of the acyl azides from a diverse selection of carboxylic acids and hydrazide starting synthons. The reaction scope was extended to include the synthesis of imidodiphosphates and the natural product Microcin C.
- Publisher
- ACS
- Research Division(s)
- Chemical Biology
- PubMed ID
- 33379864
- Publisher's Version
- https://doi.org/10.1021/acs.orglett.0c03987
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-03-09 08:05:41
Last Modified: 2021-04-28 08:23:01