CRISPR base editing applications for identifying cancer-driving mutations
- Author(s)
- Pal, M; Herold, MJ;
- Details
- Publication Year 2021-01-15,Volume 49,Issue #1,Page 269-280
- Journal Title
- Biochemical Society Transactions
- Abstract
- CRISPR base editing technology is a promising genome editing tool as (i) it does not require a DNA template to introduce mutations and (ii) it avoids creating DNA double-strand breaks, which can lead to unintended chromosomal alterations or elicit an unwanted DNA damage response. Given many cancers originate from point mutations in cancer-driving genes, the application of base editing for either modelling tumour development, therapeutic editing, or functional screening is of great promise. In this review, we summarise current DNA base editing technologies and will discuss recent advancements and existing hurdles for its usage in cancer research.
- Publisher
- Portland Press
- Keywords
- Crispr; base editor; cancer
- Research Division(s)
- Blood Cells And Blood Cancer
- PubMed ID
- 33449100
- Publisher's Version
- https://doi.org/10.1042/bst20200550
- Open Access at Publisher's Site
https://doi.org/10.1042/bst20200550- NHMRC Grants
- NHMRC/1145728, NHMRC/1143105,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-03-09 08:05:47
Last Modified: 2021-03-09 08:42:44