Natural killer cells in inflammatory autoimmune diseases
- Author(s)
- Yang, Y; Day, J; Souza-Fonseca Guimaraes, F; Wicks, IP; Louis, C;
- Details
- Publication Year 2021,Volume 10,Issue #2,Page e1250
- Journal Title
- Clinical & Translational Immunology
- Abstract
- Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help control local immune responses. Through natural cytotoxicity, production of cytokines and chemokines, and migratory capacity, NK cells play a vital immunoregulatory role in the initiation and chronicity of inflammatory and autoimmune responses. Our understanding of their functional differences and contributions in disease settings is evolving owing to new genetic and functional murine proof-of-concept studies. Here, we summarise current understanding of NK cells in several classic autoimmune disorders, particularly in rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (T1DM), but also less understood diseases such as idiopathic inflammatory myopathies (IIMs). A better understanding of how NK cells contribute to these autoimmune disorders may pave the way for NK cell-targeted therapeutics.
- Publisher
- Wiley
- Keywords
- autoimmune disease; idiopathic inflammatory myopathies; multiple sclerosis; natural killer cells; rheumatoid arthritis; systemic lupus erythematosus; type 1 diabetes mellitus
- Research Division(s)
- Inflammation
- PubMed ID
- 33552511
- Publisher's Version
- https://doi.org/10.1002/cti2.1250
- Open Access at Publisher's Site
https://doi.org/10.1002/cti2.1250- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-03-09 01:37:11
Last Modified: 2021-03-09 03:04:42