K29/K48-branched ubiquitin chains TRIP the alarm fueling neo-substrate degradation via the CRL2(VHL)
Author(s)
Magtoto, CM; Feltham, R;
Details
Publication Year 2021-04-01, Volume 81, Issue #7, Page 1363-1365
Journal Title
Molecular Cell
Abstract
In this issue of Molecular Cell, Kaiho-Soma et al. (2021) demonstrate that the HECT-type E3 ubiquitin ligase TRIP12 cooperates with CRL complexes to promote PROTAC-induced degradation of neo-substrates by generating K29/K48-branched ubiquitin chains.
Publisher
Cell Press
Keywords
Lysine/metabolism; *Ubiquitin/metabolism; *Ubiquitin-Protein Ligases/genetics/metabolism; Ubiquitination
WEHI Research Division(s)
Ubiquitin Signalling; Ubiquitin Signalling
PubMed ID
33798411
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2021-04-28 08:15:52
Last Modified: 2021-05-06 09:12:20
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