K29/K48-branched ubiquitin chains TRIP the alarm fueling neo-substrate degradation via the CRL2(VHL)
- Author(s)
- Magtoto, CM; Feltham, R;
- Details
- Publication Year 2021-04-01,Volume 81,Issue #7,Page 1363-1365
- Journal Title
- Molecular Cell
- Abstract
- In this issue of Molecular Cell, Kaiho-Soma et al. (2021) demonstrate that the HECT-type E3 ubiquitin ligase TRIP12 cooperates with CRL complexes to promote PROTAC-induced degradation of neo-substrates by generating K29/K48-branched ubiquitin chains.
- Publisher
- Cell Press
- Keywords
- Lysine/metabolism; *Ubiquitin/metabolism; *Ubiquitin-Protein Ligases/genetics/metabolism; Ubiquitination
- Research Division(s)
- Ubiquitin Signalling
- PubMed ID
- 33798411
- Publisher's Version
- https://doi.org/10.1016/j.molcel.2021.02.030
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-04-28 08:15:52
Last Modified: 2021-05-06 09:12:20