Tertiary lymphoid structures and B lymphocytes in cancer prognosis and response to immunotherapies
- Author(s)
- Jacquelot, N; Tellier, J; Nutt, SL; Belz, GT;
- Details
- Publication Year 2021-03-29,Volume 10,Issue #1,Page 1900508
- Journal Title
- Oncoimmunology
- Abstract
- Tertiary lymphoid structures (TLS) are ectopic cellular aggregates that resemble secondary lymphoid organs in their composition and structural organization. In contrast to secondary lymphoid organs, TLS are not imprinted during embryogenesis but are formed in non-lymphoid tissues in response to local inflammation. TLS structures exhibiting a variable degree of maturation are found in solid tumors. They are composed of various immune cell types including dendritic cells and antigen-specific B and T lymphocytes, that together, actively drive the immune response against tumor development and progression. This review highlights the successive steps leading to tumor TLS formation and its association with clinical outcomes. We discuss the role played by tumor-infiltrating B lymphocytes and plasma cells, their prognostic value in solid tumors and immunotherapeutic responses and their potential for future targeting.
- Publisher
- Taylor & Francis
- Keywords
- Tertiary lymphoid structures; b lymphocytes; cancer; immunotherapy; plasma cells
- Research Division(s)
- Immunology
- PubMed ID
- 33854820
- Publisher's Version
- https://doi.org/10.1080/2162402x.2021.1900508
- Open Access at Publisher's Site
https://doi.org/10.1080/2162402X.2021.1900508- NHMRC Grants
- NHMRC/1122277, NHMRC/1135898,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-05-11 02:09:48
Last Modified: 2021-05-11 02:22:30