Measuring and modelling the epithelial- mesenchymal hybrid state in cancer: clinical implications
Journal Title
Cells Tissues Organs
Publication Type
epub ahead of print
Abstract
The epithelial-mesenchymal (E/M) hybrid state has emerged as an important mediator of elements of cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). We review here evidence for the presence, prognostic significance, and therapeutic potential of the E/M hybrid state in carcinoma. We further assess modelling predictions and validation studies to demonstrate stabilised E/M hybrid states along the spectrum of EMP, as well as computational approaches for characterising and quantifying EMP phenotypes, with particular attention to the emerging realm of single-cell approaches through RNA sequencing and protein-based techniques.
Publisher
Karger
Keywords
Cancer; Computational biology; Epithelial-mesenchymal plasticity; Epithelial-mesenchymal transition; Mesenchymal- epithelial transition; E/M hybrid; Molecular modelling; Partial epithelial- mesenchymal plasticity
WEHI Research Division(s)
Bioinformatics
PubMed ID
33902034
Publisher's Version
https://doi.org/10.1159/000515289
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2021-05-11 04:12:10
Last Modified: 2021-05-17 11:11:25
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