Heterochromatin and Polycomb as regulators of haematopoiesis
- Author(s)
- Keenan, CR;
- Journal Title
- Biochemical Society Transactions
- Publication Type
- epub ahead of print
- Abstract
- Haematopoiesis is the process by which multipotent haematopoietic stem cells are transformed into each and every type of terminally differentiated blood cell. Epigenetic silencing is critical for this process by regulating the transcription of cell-cycle genes critical for self-renewal and differentiation, as well as restricting alternative fate genes to allow lineage commitment and appropriate differentiation. There are two distinct forms of transcriptionally repressed chromatin: H3K9me3-marked heterochromatin and H3K27me3/H2AK119ub1-marked Polycomb (often referred to as facultative heterochromatin). This review will discuss the role of these distinct epigenetic silencing mechanisms in regulating normal haematopoiesis, how these contribute to age-related haematopoietic dysfunction, and the rationale for therapeutic targeting of these pathways in the treatment of haematological malignancies.
- Publisher
- Portland Press
- Keywords
- Prc2; Suv39h1/2; blood cancer; cell differentiation; epigenetic silencing; haematopoietic stem cells
- Research Division(s)
- Immunology
- Publisher's Version
- https://doi.org/10.1042/bst20200737
- Open Access at Publisher's Site
https://doi.org/10.1042/BST20200737- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-05-11 04:12:10
Last Modified: 2021-05-17 11:12:20