For whom the bell tolls: the structure of the dead kinase, IRAK3
- Author(s)
- Horne, CR; Murphy, JM;
- Details
- Publication Year 2021-03-04,Volume 29,Issue #3,Page 197-199
- Journal Title
- Structure
- Abstract
- In this issue of Structure, Lange et al. (2020) report the structure of the pseudokinase domain of IRAK3, a negative regulator of Myddosome inflammatory signaling. The IRAK3 pseudokinase domain forms a head-to-head dimer, suggesting a new mode of kinase/pseudokinase allostery by which IRAK3 could attenuate the activity of IRAK4 in cells.
- Publisher
- Cell Press
- Research Division(s)
- Inflammation
- PubMed ID
- 33667374
- Publisher's Version
- https://doi.org/10.1016/j.str.2021.01.011
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-05-13 09:20:17
Last Modified: 2021-05-13 09:24:13