Understanding insulin and its receptor from their three-dimensional structure
- Author(s)
- Lawrence, MC;
- Journal Title
- Molecular Metabolism
- Publication Type
- epub ahead of print
- Abstract
- BACKGROUND: The discovery of insulin 100 years ago and its ongoing use since that time in the treatment of diabetes belies the molecular complexity of its structure and that of its receptor. Advances in single-particle cryo-electron microscopy have over the past three years revolutionized our understanding of the atomic detail of the insulin insulin-receptor interaction. SCOPE OF THE REVIEW: The review describes the three-dimensional structure of insulin and its receptor and the detail of the way in which they interact. The review also highlights the current gaps in our structural understanding of the system. MAJOR CONCLUSIONS: A near-complete picture has been obtained of the hormone receptor interaction, providing new insights into the kinetics of the interaction and necessitating a revision of the extant two-site cross-linking model of hormone receptor engagement. How insulin initially engages the receptor and the trajectory traversed by the receptor as it undergoes the conformational changes associated with activation remain areas for future investigation.
- Publisher
- Elsevier
- Keywords
- Cryo-Electron Microscopy; Insulin; Insulin Receptor; Protein Structure; Receptor Tyrosine Kinase; X-Ray Crystallography
- Research Division(s)
- Structural Biology
- PubMed ID
- 33992784
- Publisher's Version
- https://doi.org/10.1016/j.molmet.2021.101255
- Open Access at Publisher's Site
https://doi.org/10.1016/j.molmet.2021.101255- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-06-02 01:46:01
Last Modified: 2021-06-02 01:52:25