Late stage phosphotyrosine mimetic functionalization of peptides employing metallaphotoredox catalysis
- Author(s)
- Chen, H; Mao, R; Brzozowski, M; Nguyen, NH; Sleebs, BE;
- Details
- Publication Year 2021-05-24,Volume 23,Issue #11,Page 4244-4249
- Journal Title
- Organic letters
- Publication Type
- epub ahead of print
- Abstract
- Access to phosphotyrosine (pTyr) mimetics requires multistep syntheses, and therefore late stage incorporation of these mimetics into peptides is not feasible. Here, we develop and employ metallaphotoredox catalysis using 4-halogenated phenylalanine to afford a variety of protected pTyr mimetics in one step. This methodology was shown to be tolerant of common protecting groups and applicable to the late stage pTyr mimetic modification of protected and unprotected peptides, and peptides of biological relevance.
- Publisher
- ACS
- Research Division(s)
- Chemical Biology; Ubiquitin Signalling
- PubMed ID
- 34029466
- Publisher's Version
- https://doi.org/10.1021/acs.orglett.1c01200
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-06-02 01:55:17
Last Modified: 2021-07-07 11:40:38