High dimensional mass cytometry identifies T cell and B cell signatures predicting reduced risk of Plasmodium vivax malaria
Journal Title
JCI Insight
Publication Type
epub ahead of print
Abstract
IFN-gamma-driven responses to malaria have been shown to modulate the development and function of T follicular helper (TFH) cells and memory B cells (MBCs), with conflicting evidence in their involvement in the induction of antibody responses required to achieve clinical immunity and their association with disease outcomes. Using high-dimensional single cell mass cytometry, we identified distinct populations of TH1-polarized CD4+ T cells and MBCs expressing the TH1-defining transcription factor T-bet, associated with either increased or reduced risk of Plasmodium vivax malaria, demonstrating that inflammatory responses to malaria are not universally detrimental for infection. Furthermore, we found that whereas class-switched but not IgM+ MBCs were associated with reduced risk of symptomatic malaria, populations of TH1 cells with a stem central memory phenotype, TH17 cells and T regulatory cells were associated with protection from asymptomatic infection, suggesting that activation of cell mediated immunity might be also required to control persistent P. vivax infection of low parasite burden.
Publisher
ACSCI
WEHI Research Division(s)
Infectious Diseases And Immune Defence; Bioinformatics; Population Health And Immunity
PubMed ID
34128836
Open Access at Publisher's Site
https://doi.org/10.1172/jci.insight.148086
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2021-06-21 10:26:00
Last Modified: 2021-06-21 10:43:33
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