The gene regulatory network controlling plasma cell function
Author(s)
Trezise, S; Nutt, SL;
Journal Title
Immunological Reviews
Publication Type
epub ahead of print
Abstract
Antibodies are an essential element of the immune response to infection, and in long-term protection upon re-exposure to the same micro-organism. Antibodies are produced by plasmablasts and plasma cells, the terminally differentiated cells of the B lymphocyte lineage. These relatively rare populations, collectively termed antibody secreting cells (ASCs), have developed highly specialized transcriptional and metabolic pathways to facilitate their extraordinarily high rates of antibody synthesis and secretion. In this review, we discuss the gene regulatory network that controls ASC identity and function, with a particular focus on the processes that influence the transcription, translation, folding, modification and secretion of antibodies. We will address how ASCs have adapted their transcriptional, metabolic and protein homeostasis pathways to sustain such high rates of antibody production, and the roles that the major ASC regulators, the transcription factors, Irf4, Blimp-1 and Xbp1, play in co-ordinating these processes.
Publisher
Wiley
Keywords
B cell differentiation; antibody secretion; plasma cell; unfolded protein response
WEHI Research Division(s)
Immunology
PubMed ID
34109653
Publisher's Version
https://doi.org/10.1111/imr.12988
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2021-06-21 10:26:04
Last Modified: 2021-06-21 10:47:32
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