CD36 family members are TCR-independent ligands for CD1 antigen-presenting molecules

Gherardin, NA; Redmond, SJ; McWilliam, HEG; Almeida, CF; Gourley, KHA; Seneviratna, R; Li, S; De Rose, R; Ross, FJ; Nguyen-Robertson, CV; Su, S; Ritchie, ME; Villadangos, JA; Moody, DB; Pellicci, DG; Uldrich, AP; Godfrey, DI

Author(s): Gherardin, NA; Redmond, SJ; McWilliam, HEG; Almeida, CF; Gourley, KHA; Seneviratna, R; Li, S; De Rose, R; Ross, FJ; Nguyen-Robertson, CV; Su, S; Ritchie, ME; Villadangos, JA; Moody, DB; Pellicci, DG; Uldrich, AP; Godfrey, DI;
Details: Publication Year 2021-06-25,Volume 6,Issue #60,Page eabg4176
Journal Title: Science Immunology
Abstract: CD1c presents lipid-based antigens to CD1c-restricted T cells, which are thought to be a major component of the human T cell pool. However, the study of CD1c-restricted T cells is hampered by the presence of an abundantly expressed, non-T cell receptor (TCR) ligand for CD1c on blood cells, confounding analysis of TCR-mediated CD1c tetramer staining. Here, we identified the CD36 family (CD36, SR-B1, and LIMP-2) as ligands for CD1c, CD1b, and CD1d proteins and showed that CD36 is the receptor responsible for non-TCR-mediated CD1c tetramer staining of blood cells. Moreover, CD36 blockade clarified tetramer-based identification of CD1c-restricted T cells and improved identification of CD1b- and CD1d-restricted T cells. We used this technique to characterize CD1c-restricted T cells ex vivo and showed diverse phenotypic features, TCR repertoire, and antigen-specific subsets. Accordingly, this work will enable further studies into the biology of CD1 and human CD1-restricted T cells.
Publisher: AAAS
Research Division(s): Epigenetics And Development
PubMed ID: 34172588
Link To PubMed Central Version: http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8418821/
Publisher's Version: https://doi.org/10.1126/sciimmunol.abg4176
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2021-06-30 12:00:54

Last Modified: 2022-02-28 02:09:13