IgG antibody responses are preferential compared with IgM for use as serological markers for detecting recent exposure to Plasmodium vivax infection
Details
Publication Year 2021-06, Volume 8, Issue #6, Page ofab228
Journal Title
Open Forum Infectious Diseases
Abstract
To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax. Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, immunoglobulin M (IgM) in addition to immunoglobulin G (IgG) antibody responses were compared with a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG.
Publisher
Oxford Academic
Keywords
IgG; IgM; Plasmodium vivax; antibody; malaria; serological exposure markers; serology; surveillance
WEHI Research Division(s)
Population Health And Immunity; Infectious Diseases And Immune Defence
PubMed ID
34159216
Open Access at Publisher's Site
https://doi.org/10.1093/ofid/ofab228
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2021-06-30 12:00:55
Last Modified: 2021-07-20 02:57:06
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