IgG antibody responses are preferential compared with IgM for use as serological markers for detecting recent exposure to Plasmodium vivax infection
- Author(s)
- Longley, RJ; White, MT; Brewster, J; Liu, ZSJ; Bourke, C; Takashima, E; Harbers, M; Tham, WH; Healer, J; Chitnis, CE; Monteiro, W; Lacerda, M; Sattabongkot, J; Tsuboi, T; Mueller, I;
- Details
- Publication Year 2021-06,Volume 8,Issue #6,Page ofab228
- Journal Title
- Open Forum Infectious Diseases
- Abstract
- To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax. Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, immunoglobulin M (IgM) in addition to immunoglobulin G (IgG) antibody responses were compared with a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG.
- Publisher
- Oxford Academic
- Keywords
- IgG; IgM; Plasmodium vivax; antibody; malaria; serological exposure markers; serology; surveillance
- Research Division(s)
- Population Health And Immunity; Infectious Diseases And Immune Defence
- PubMed ID
- 34159216
- Publisher's Version
- https://doi.org/10.1093/ofid/ofab228
- Open Access at Publisher's Site
https://doi.org/10.1093/ofid/ofab228- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2021-06-30 12:00:55
Last Modified: 2021-07-20 02:57:06