B cells in lung cancer-not just a bystander cell: A literature review
Author(s)
Leong, TL; Bryant, VL;
Details
Publication Year 2021,Volume 10,Issue #6,Page 2830-2841
Journal Title
Translational Lung Cancer Research
Abstract
Metastatic lung cancer represents a significant global issue where it is responsible for the most cancer diagnoses and deaths worldwide. Treatment for advanced lung cancer has undergone a series of paradigm shifts from chemotherapy to targeted molecular agents to the most recent immunotherapy strategies. The most successful of the latter involves antibodies that block inhibitory receptors on tumor infiltrating T cells, thereby enhancing T cell activity against tumor cells. However, only a subset of patients demonstrate durable responses to these drugs and treatment resistance is common. Emerging evidence suggests that a critical role exists for B cells as more than a bystander immune cell in the tumor microenvironment (TME). However, this role is likely context-specific where B cells comprise distinct subtypes with unique effector functions that may result in anti- or pro-tumor effects. As such, the balance between various B cell subtypes affects the net B cell impact upon tumor immunity. To date, the factors needed to polarize B cell function toward anti-tumor activity are unclear. Understanding B cell biology in the lung cancer setting will help redefine and refine treatment strategies to augment anti-tumor immunity. This article presents a review of the literature describing the current knowledge of the development and function of B cells, and explores their role in lung cancer and potential as an immunotherapeutic strategy and as a predictive marker for response to immune checkpoint blockade. © 2021 AME Publishing Company. All rights reserved.
Publisher
AME Publishing Company
Keywords
B cell; B lymphocyte; Immune checkpoint inhibitors (ICIs); Immunotherapy; Lung cancer
Research Division(s)
Personalised Oncology; Immunology
Open Access at Publisher's Site
https://doi.org/10.21037/tlcr-20-788
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2021-07-20 11:18:10
Last Modified: 2021-07-20 12:48:20
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